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© 2007 Society of Cosmetic Chemists
Journal of the Society of Cosmetic Chemists, Vol. 58, No. 2, 157-171


Preparation and stability of cosmetic formulations with an anti-aging peptide
M. A. Ruiz , B. Clares , M. E. Morales , S. Cazalla , V. Gallardo

ABSTRACT

Synopsis

Wrinkling of the skin is the most obvious sign of deterioration of the human body with age. This process involves a number of genetic, constitutional, hormonal, nutritional, and environmental factors, in addition to the influence of frequently repeated facial movements during laughing, smoking, etc. This article reviews the physiological basis and mechanism of action of the active cosmetic ingredient acetyl hexapeptide-8 (Argireline®). We prepared two formulations: an emulsion with an external aqueous phase for normal to dry skin, and a gel for oily skin. Laboratory analyses, rheology tests and in vitro release assays were used to evaluate the stability of these formulations for cosmetic treatment.

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© 2007 Society of Cosmetic Chemists
Journal of the Society of Cosmetic Chemists