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© 2002 Society of Cosmetic Chemists
Journal of the Society of Cosmetic Chemists, Vol. 53, No. 4, 209-218


An in vitro, ex vivo, and in vivo demonstration of the lipolytic effect of slimming liposomes: An unexpected α2-adrenergic antagonism
L. Tholon , G. Neliat , C. Chesne , D. Saboureau , E. Perrier , J.-E. Branka

ABSTRACT

Synopsis

Most of the slimming products already developed for cosmetic applications did not result from strategies that integrate whole lipolysis-regulating mechanisms. We thus focused our attention on a more complete integration of these mechanisms and we developed slimming liposomes (SLC) containing two microcirculation activators, i.e., esculoside and Centella asiatica extracts, one phosphodiesterase inhibitor, i.e., caffeine, and one fatty acid-β oxidation activator, i.e., L-carnitine.

The validity of our approach was assessed through (a) in vitro tests demonstrating that SLC induced a dramatic increase in the cyclic adenosine monophosphate (cAMP) content in human adipocytes, with a subsequent rise in the nonesterified fatty acids (NEFA) content of human adipocyte incubation medium, and (b) in vivo studies showing that SLC could provide an actual potent slimming effect on human volunteers.

Moreover, we give here, through binding experiments, the unambiguous demonstration that SLC is able to antagonize the α 2 -adrenergic receptor that is known to reduce intracellular AMPc content and, subsequently, to down-regulate lipolysis. This α 2 -adrenergic antagonism has never been reported for any component of SLC, and this work is the first demonstration of the α 2 -adrenergic antagonism of such a combination of active liposome compounds.

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© 2002 Society of Cosmetic Chemists
Journal of the Society of Cosmetic Chemists