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© 2000 Society of Cosmetic Chemists
Journal of the Society of Cosmetic Chemists, Vol. 51, No. 3, 153-167


Development of a modified forearm controlled application test method for evaluating the skin mildness of disposable wipe products
Miranda A. Farage

ABSTRACT

Synopsis

A modified forearm conrrolled application technique (modified FCAT) was developed to evaluate the relative mildness of baby wipe products. The test uses a semi-occlusive patch system to mimic the hydrated conditions common to the skin in the diaper area, interspersed with repeated product applications. The skin condition is scored for four endpoints: visual scoring for erythema and dryness, and instrumental scoring for redness (using a chromameter) and transepidermal water loss (TEWL by evaporimeter). The variables evaluated in the course of developing the method include the optimum patch system to achieve hydration, the specific procedure for applying the test products, and the minimum test duration required to achieve significant differences for all four endpoints. The optimum study design produces statistically significant differences between baby wipe test products in all four endpoints. This method has applicability for wipes intended for other uses where mildness and irritation are critical considerations, such as wipes intended for cosmetic removal.

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© 2000 Society of Cosmetic Chemists
Journal of the Society of Cosmetic Chemists