Influence of lamellar liquid crystal structure on percutaneous diffusion of a hydrophilic tracer from emulsions
Laure Brinon , Sandrine Geiger , Valerie Alard , Jean-François Tranchant , Thierry Pouget , Guy Couarraze

Synopsis

The purpose of this study was to investigate the effect of a lamellar liquid crystalline phase in emulsions on percutaneous diffusion of a hydrophilic sunscreen (benzophenone-4). Six emulsions were formulated, using all the same components except the surfactants. The emulsion structures were visualized by freeze-fracture electron microscopy. In vitro penetration measurements were performed with static diffusion cells.

Benzophenone-4 fluxes were smallest for emulsions without liquid crystals and highest for those with liquid crystals. The permeant fluxes seemed to be modified by the surfactant organization within the emulsions.

Full Article PDF

Table of Contents