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© 1985 Society of Cosmetic Chemists
Journal of the Society of Cosmetic Chemists, Vol. 36, No. 6, 435-440


The site of antiperspirant action by aluminum salts in the eccrine sweat glands of the axilla
Richard P. Quatrale , Eileen L. Thomas , Jay E. Birnbaum

ABSTRACT

Synopsis

The relative sites of antiperspirant activity within human axillary eccrine sweat glands of aluminum chlorohydrate (ACH), aluminum zirconium chlorohydrate glycine complex (AZAP), and aluminum chloride (AlCl 3 ) were determined by the cellophane tape stripping procedure. Using the starch\/iodine method, individual functioning sweat glands were identified prior to antiperspirant treatment, after treatment, and after tape stripping. As had been found earlier in studies of the eccrine sweat glands in the human forearm, AlCl 3 acted most deeply within the duct, whereas the sites of action for ACH and, particularly, AZAP were closer to the skin surface. On average, however, both ACH and AZAP appeared to inhibit perspiration outflow at a deeper level in more individual axillary sweat ducts than they did in forearm ducts.

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© 1985 Society of Cosmetic Chemists
Journal of the Society of Cosmetic Chemists