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© 1979 Society of Cosmetic Chemists
Journal of the Society of Cosmetic Chemists, Vol. 30, No. 5, 279-295


Mechanism of antiperspirant action of aluminum salts
Erhard Hölzle , Albert M. Kligman

ABSTRACT

Synopsis

Complete anhidrosis was induced by occlusive application of aluminum chloride hexahydrate for 3 and 24 hr. Immediately after exposure, an amorphous aluminum-containing cast was demonstrated in the sweat ducts by the fluorescent morin stain. The cast was PAS-positive, diastase-resistant and extended throughout the acrosyringium down to the upper and mid-dermis. Histologically, the luminal cells of the acrosyringium were damaged and soon sloughed, fusing with the cast. There were no inflammatory changes. The physically occluded ducts did not sweat for two to three weeks until the normal process of cell renewal resulted in replacement of the acrosyringium. ANHIDROSIS induced by ALUMINUM SALTS has unique characteristics which distinguish it from all other procedures which interfere with sweat delivery.

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© 1979 Society of Cosmetic Chemists
Journal of the Society of Cosmetic Chemists