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© 1977 Society of Cosmetic Chemists
Journal of the Society of Cosmetic Chemists, Vol. 28, No. 11, 681-694


The evaluation of fluoride dentifrices
Morton Pader , Lewis P. Cancro , Bernard Guillo

ABSTRACT

Synopsis

Four laboratory tests were investigated as indicators of the compatibility of FLUORIDE SOURCE and ABRASIVE SYSTEM in FLUORIDE DENTIFRICES. These were solubility of the fluoride in water, ability to reduce the solubility of dental enamel in acid in vitro , uptake of fluoride from the dentifrice in vitro , and a rat assay for anticaries efficacy. Dentifrices were formulated with 1000 ppm fluoride (as NaF, SnF 2 , or Na 2 PO 3 F) and with abrasives known to either interact or not interact with those particular fluorides. Also, clinically proven commercial products were examined. The assays for water-solubility of the fluoride and the rat assay clearly distinguished between the dentifrices with respect to compatibility of fluoride source and dentifrice abrasive, in agreement with the results of clinical trials reported in the literature, involving different abrasives and sources of fluoride.

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© 1977 Society of Cosmetic Chemists
Journal of the Society of Cosmetic Chemists