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© 1977 Society of Cosmetic Chemists
Journal of the Society of Cosmetic Chemists, Vol. 28, No. 11, 667-679


Reduction of topical irritation
Robert L. Goldemberg , Leopold Safrin

ABSTRACT

Synopsis

ANTIIRRITANT effects noted since 1965 are reviewed and grouped into two major chemical categories: IMIDAZOLE and HYDROXY compounds. Several miscellaneous types are also noted: PVP (Polyvinyl pyrollidone), quaternary ammonium complexes, and amido sulfosuccinate surfactants.

The “no tears” antiirritancy effect, which results from a combination of AMPHOTERIC surfactants with lauryl sulfates is postulated as resulting from a possible difference in sorption rates which allows the amphoteric to “occupy” the cornea's available binding sites before the anionic can do so, thus preventing “denaturing” damage to the eye by the lauryl sulfate.

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© 1977 Society of Cosmetic Chemists
Journal of the Society of Cosmetic Chemists