The Uptake, Distribution, and Excretion of a Commercial Aerosol Antiperspirant by the Monkey
Paul Finkelstein , Ronald J. Wulf

Synopsis

Four monkeys were exposed to the spray of an AEROSOL ANTIPERSPIRANT in a head-only exposure chamber by directing the stream directly at the face for 5 seconds. One ingredient of the formulation, ISOPRQPYL MYRISTATE, was RADIOLABELED with carbon-14. Following exposure, two animals were sacrificed immediately and two others were allowed to live for 24 hours before necropsy. The distribution of carbon-14 in several tissues, as well as in the exhaled breath, was determined.

The results indicate that only about 0.025% of the dose sprayed at the animals reached the lower respiratory tract. In 24 hours about 85% of the carbon-14 had been eliminated.

Full Article PDF

Table of Contents