Water-Insoluble Bacteriostats Solubilized in Soap and Detergent Solutions
Kenneth L. Russell , Stephen G. Hoch

Synopsis

Three nonionic surfactants, ethoxylated lanolin alcohols, ethoxylated sorbitan esters and ethoxylated nonyl phenol, were used to solubilize two water-insoluble bacteriostats, trichlorocarbanilide and mixed di- and tribromosalicylanilide, in four surfactant solutions. The maximum percentage of each bacteriostat solubilized under specific conditions by each nonionic in 20% potassium coconut soap, 20% triethanolamine lauryl sulfate, 20% triethanolamine dodecyl benzene sulfonate and a mixed amphoteric-anionic solution is reported. Only the ethoxylated lanolin alcohols were found to permit simultaneous solubilization of the bacteriostats and 1.0% lanolin oil. The inclusion of the latter increased the amounts of the bacteriostats which could be solubilized in two of the detergent solutions. The bacteriostatic and bactericidal properties of the two antibacterials solubilized in triethanolamine lauryl sulfate are compared with those of the same agents suspended in the surfactant without the nonionic solubilizer. It was found that the bacteriological activity of the solubilized agents was as great as or greater than that of the suspended materials.

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